Vitamins A, C, and E are antioxidant-rich nutrients necessary for good health. In the past, investigations on animals and lab animals found some scientific support for using antioxidant vitamins in the treatment of rheumatoid arthritis. Osteoarthritis investigations have yielded varied results regarding the usefulness of vitamin E. It’s heartening to see promising results from early trials of vitamin C in treating osteoarthritis, but larger studies are needed to validate these findings.

  • Family: Supplemental food and nutrition
  • All three of these nutrients are known as “retinoids” in the scientific community (tocopherols and tocotrienols)

Vitamins are essential nutrients consumed at trace levels to maintain good health. Unlike water-soluble vitamins, fat-soluble vitamins A and E must be replenished regularly since they are stored in fat cells. Because it’s a water-soluble vitamin, vitamin C is a potent antioxidant. Except for vitamin B12, your body stores water-soluble vitamins for only a brief time before excreting them in your urine. Your body won’t absorb the water-soluble vitamins you need if you don’t.

What is the mechanism by which they operate?

Antioxidant qualities are found in vitamins A, C, and E. As a result, they can counteract the production of dangerous molecules known as free radicals, which can cause tissue damage or disease. Vitamin C, for example, is known to be a source of antioxidants in the diet that can help neutralize excess free radicals in the body.

According to several laboratory and animal research, the growth of cartilage cells may also be stimulated by vitamin E. A few anti-inflammatory activities were also discovered in other research on this substance.

Anti-inflammatory drug trials in patients with rheumatoid arthritis

  • Vitamin E may play a role in treating rheumatoid arthritis in three of the four trials in this review paper, while selenium ACE therapy was evaluated in the fourth.
  • There was no significant difference in morning stiffness, several swollen joints, and degree of joint soreness between participants on 1,200 mg per day of vitamin E supplementation or a placebo. However, those getting vitamin E saw a considerable reduction in pain.
  • In both the second and third trials (41 and 85 participants, respectively), there was no significant difference in illness severity between those given 1,200 mg a day of vitamin E supplements and those given 150 mg of diclofenac (a non-steroidal anti-inflammatory medicine) a day.
  • In the fourth trial, which included 20 persons over six months, researchers found no significant difference in disease severity between those who took selenium ACE supplements and those who received a placebo.